Several experimental studies have been performed in order to evaluate the behavior of different types of biomaterials involved in the process of tissue and bone regeneration. The guided bone regeneration (GBR) principles are applied in the rebuilding of periodontal tissues, damaged by the periodontal inflammatory process. Since the introduction of GBR biological principles, a wide range of materials have been tested and used as a physical barrier. At present, the autogenous material continues to be considered the best choice when reconstruction of bone defects is intended. Calcium phosphate ceramics have been widely applied as bone substitutes, coatings, cements, drug delivery systems and tissue engineering scaffolds due to their resemblance to the mineral portion of the bone tissue, relative ease in processing and good cell attachment. 40 patients (25 males and 15 females) planned to receive bone regeneration procedure were included in the study. 20 patients were treated for bone regeneration using just BondBone, 10 patients using BondBone and a Collagen membrane and the remaining 10 patients with Bone substitute and a collagen membrane. This study has evaluates the bone tissue behavior of calcium sulfate barrier in bone repair in human bone, observing the GBR biological principles. We can conlude that calcium sulfate can work as a completion material, space maintainer, vehicle for a controlled release of certain drugs, associated with other graft materials.

Lesions of the oral mucosa represent a diagnostic challenge for dental practitioners, because similar appearances are the final common manifestation of a wide spectrum of conditions, including autoimmune diseases; neoplastic, traumatic, or infectious lesions; nutritional deficiencies; and drug reactions, as well as oral manifestations of systemic diseases. One of the roles of dental practitioners is the identification and management of oral mucosa diseases. While the diagnosis of some oral lesions can be made on the basis of the history and/or clinical findings, for others, the definitive diagnosis requires the aid of some tools with which the general dentist should be familiar.

Long noncoding RNAs (lncRNAs) are often dysregulated in cancer tissue and seem to play an important role in neoplastic processes. Recent studies have shown that the HOX transcript antisense intergenic RNA (HOTAIR) may play a role as a marker of prognosis in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to perform a meta-analysis of studies focused on the prognostic role of HOTAIR in SCCHN.

The use of piezo surgery is characterized by a good cutting ability associated with a higher soft tissues respect. Such skills have led to an increment of the use of such systematic in the clinical practice. The aim of this study was to figure out whether the use of piezo surgery may show clinical advantages when enucleation is followed by peripheral ostectomy for the treatment of solid/multicystic ameloblastoma. A retrospective case-control study was performed, including patients treated with piezo surgery or conventional drilling in a single center in Italy. Results of this investigation revealed a lower rate of relapse, at 5 years' follow-up for patients treated with piezo surgery. Although characterized by low power of evidences, the results of this investigation encourage the development of further studies related to the use of piezo surgery for the treatment of solid/multicystic ameloblastoma.

Recurrent aphtous stomatitis (RAS; recurrent aphtous ulcers, canker sores) is the most common ulcerative disease of the oral mucosa. In this paper we presented the main clinical features, epidemiologic data, etiopathogenetic factors and clinical management, based on the current medical literature reports.

Delay in diagnosing oral squamous cell carcinoma (OSCC) can be still identified as a major cause of its high morbidity and mortality. To date, the early diagnosis for OSCC is mainly based on clinical oral examination and there is an urgent need for reliable markers; thus, advancements in molecular technologies has set the stage for investigating new markers, as well as new diagnostic matrices. The aim of the present study is to investigate the presence of proteomic signatures of OSCC in saliva and their use as potential biomarkers for early and non-invasive diagnosis. Saliva from 45 OSCC patients and 30 healthy controls was analysed by SELDI-TOF mass spectrometry and ProteinChip (R) technology. A supervised multivariate statistical analysis (Classification and Regression Tree - CART) was used to build models for discriminating between OSCC and controls, and between early (ES-OSCC) and late stage (LS-OSCC) cancers. The peptide with 8041 Da mass was 22-fold more expressed in OSCC, thus being a suitable potential biomarker. Classification and regression analysis allowed to build a model that was capable of correctly classifying all cancers and controls in an independent testing set, using the 8041 ink peak as splitter. Eleven peaks were also differently expressed between ES-OSCC and LS-OSCC, but, basing on these differences, it was not possible to build an algorithm to predict tumour staging. These findings confirm that saliva proteome in OSCC patients is different from healthy controls and these variations might reflect different stages of disease progression and are worthy of further validation as diagnostic and prognostic biomarkers.

Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide an increasing number of people ? 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.

To investigate the quality of sleep and the psychological profiles of a large cohort of Italian patients with burning mouth syndrome (BMS) and to clarify the relationships between these variables and pain.

L’invenzione di cui trattasi ha per oggetto l’impiego di Polidatina per il trattamento e la prevenzione dell’osteoporosi