Searching For New Targets And Treatments In The Battle Against Squamous Cell Carcinoma Of The Head And Neck, With Specific Focus On Tumours Of The Tongue

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Abstract

Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide an increasing number of people ? 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.

Autore Pugliese

Tutti gli autori

  • Sgaramella Nicola , Gu Xiaolian , Boldrup Linda , Coates Philip J , Fahraeus Robin , Califano Luigi , Tartaro Gianpaolo , Colella Giuseppe , Spaak Lena Norberg , Strom Adrian , Wilms Torben , Lo Muzio Lorenzo , Orabona Giovanni Dell'Aversana , Santagata Mario , Loljung Lotta , Rossiello Riccardo , Danielsson Karin , Strindlund Klas , Lillqvist Sandra , Nylander Karin

Titolo volume/Rivista

CURRENT TOPICS IN MEDICINAL CHEMISTRY

Anno di pubblicazione

2018

ISSN

1568-0266

ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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