The internalisation efficiency and cytotoxicity of polymeric microparticles and capsules were studiedfor three different adherent cell lines: HeLa (human cervice cancer), MCF-7 (human breast cancer)and B104 (murine neuroblastoma). Microparticles of colloidal CaCO3 cores coated with either layerby-layer self-assembled oppositely charged biosynthetic (PSS\PAH) or biodegradable (DXS\PRM)polyelectrolytes and hollow capsules thereof, obtained upon removal of the CaCO3 cores by EDTA,were fabricated. Fluorescent-labeled polymer layers coated onto CaCO3 cores were employed forevaluating cell uptake efficiency. Confocal laser scanning microscopy was used to confirm dissolutionof preformed biodegradable multilayers. Cellular viability for all type of colloidal entities waspreserved, indicating safety and tolerability of the potential drug carriers.

Increasing the ease and the rapidity of processing in micro and nanotechnology is an ongoing task, which is pursued in both the academic environment for investigation of novel systems and in industry for fabrication of complex circuits on a large scale. In the field of nanoelectronics, the major challenge is to demonstrate a feasible method for device implementation based on individual nanosize objects, such as nanowires, nanotubes and nanocrystals. However, integrating these small objects in a macroscopic circuit is a difficult task. So far, nanostructures have been wired by highly sophisticated techniques not suitable for large-scale integration in macroscopic circuits, such as electron-beam lithography or focused ion-beam deposition. Here we present a 'one-pot' and rapid approach to electrically interconnect individual nanowires from random spatial distribution, with high spatial and positioning resolution and a remarkable reduction in overall fabrication time with respect to the other expensive and laborious techniques. The reliability of such technique is demonstrated by implementing a single semiconductor nanowire device