We perform a global analysis of neutrino oscillation data, including high-precision measurements of the neutrino mixing angle theta(13) at reactor experiments, which have confirmed previous indications in favor of theta(13) > 0. Recent data presented at the Neutrino 2012 conference are also included. We focus on the correlations between theta(13) and the mixing angle theta(23), as well as between theta(13) and the neutrino CP-violation phase delta. We find interesting indications for theta(23) < pi/4 and possible hints for delta similar to pi, with no significant difference between normal and inverted mass hierarchy.

Recent studies have evidenced that long-baseline (LBL) experiments are sensitive to the extra CP-phases involved with light sterile neutrinos, whose existence is suggested by several anomalous short-baseline (SBL) results. We show that, within the 3+1 scheme, the combination of the existing SBL data with the LBL results coming from the two currently running experiments NO$\nu$A and T2K, enables us to simultaneously constrain two active-sterile mixing angles $ heta_14$ and $ heta_24$ and two CP-phases $\delta_13 \equiv \delta$ and $\delta_14$, albeit the information on the second CP-phase is still weak at the moment. The two mixing angles are basically determined by the SBL data, while the two CP-phases are constrained by the LBL experiments, once the information coming from the SBL setups is taken into account. We also assess the robustness/fragility of the estimates of the standard 3-flavor parameters in the more general 3+1 scheme. To this regard we find that: i) the indication of CP-violation found in the 3-flavor analyses persists also in the 3+1 scheme, with $\delta_13 \equiv \delta$ having still its best fit value around $-\pi/2$; ii) the 3-flavor weak hint in favor of the normal hierarchy becomes even less significant when sterile neutrinos come into play; iii) the weak indication of non-maximal $ heta_23$ (driven by NO$\nu$A disappearance data) persists in the 3+1 scheme, where maximal mixing is disfavored at almost the 90\% C.L. in both normal and inverted mass hierarchy; iv) the preference in favor of one of the two octants of $ heta_23$ found in the 3-flavor framework (higher octant for inverted mass hierarchy) is completely washed out in the 3+1 scheme.

L’invenzione si riferisce all’uso dei promotori derivati dagli elementi trasponibili Bari1 e Bari3, appartenenti alla famiglia degli elementi Bari, per l’attivazione trascrizionale di geni in sistemi procariotici ed eucariotici. Entrambi i promotori oggetto dell’invenzione sono infatti in grado di attivare la trascrizione di geni posti a valle in cellule umane, di insetto e batteriche. Il trovato può essere vantaggiosamente utilizzato per la costruzione di vettori di espressione utilizzabili in vivo ed in vitro per l’espressione di transgeni in sistemi eucariotici e procariotici di comune interesse biotecnologico senza la necessità di dover utilizzare sistemi di espressione ospite-specifici. L’invenzione si pone come valida alternativa ai sistemi di espressione attualmente disponibili rendendo immediatamente possibile uno switch tra diversi sistemi sperimentali, riducendo costi e tempi della sperimentazione. Il mercato a cui si rivolge il trovato è relativo a quello delle aziende biotech, in particolare quelle che sviluppano tools di espressione in vivo ed in vitro basati su vettori di espressione virali e non-virali, per l’industria, la terapia genica e la ricerca di base.

The invention refers to 5'TIR nucleotide sequences derived from the "Bari" family of transposable elements for the use as promoter in the expression of a transgene in a recombinant genetic construct adapted to be transfected in a host cell system.