Abstract

Searching for effective therapeutic agents?? to ??prevent? ?neurodegeneration ?is a challenging task due ?to ?the growing list of neurodegenerative disorders associated with a multitude of inter-related pathways.? The induction and inhibition of several different signaling pathways has been shown to slow down and/or attenuate ?neurodegeneration and decline in cognition and locomotor function. Among these signaling pathways, a new class of enzymes known as sirtuins or silent information regulators of gene transcription has been shown to play important regulatory roles in the ageing process. SIRT1, a nuclear sirtuin, has received ?particular interest due to its role as a deacetylase for several metabolic and signaling proteins involved in stress response, apoptosis, mitochondrial function, self-renewal, and ?neuroprotection. ?A new strategy to treat ?neurodegenerative diseases is targeted therapy. In ?this ?paper, we? ? reviewed up-to-date findings regarding the targeting of ?SIRT1 by polyphenolic ?compounds,? ?as a ?new ??approach in the search for novel, safe and effective treatments for ? ?neurodegenerative ?diseases. ?

Autore Pugliese

• Vacca Rosa Anna

Tutti gli autori

• Ajami M.; Pazoki-Toroudi H.; Amani H.; Nabavi S.F.; Braidy N.; Vacca R.A.; Atanasov A.G.; Mocan A.; Nabavi S.M.

Titolo volume/Rivista

Neuroscience and biobehavioral reviews

Anno di pubblicazione

2017

ISSN

0149-7634

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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