Preliminary clinical validation of a new ultrasound-based methodology for femoral neck densitometry

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Abstract

Hip fracture has been recognized as the worstconsequence of osteoporosis, as it represents one of the mostimportant causes of disability and mortality in elderlypeople. An accurate knowledge of the osteoporotic fracturerisk in asymptomatic individuals through population massscreenings may be the only way to reduce the occurrence ofhip fractures. Aim of this study was to perform apreliminary clinical validation of a new ultrasound (US)-based method for bone densitometry directly applicable onfemoral neck. A total of 112 female patients were enrolledfor this study (61-75 years of age, body mass index(BMI)<40 kg/m2) and all of them underwent two differentdiagnostic investigations: a conventional DXA (dual-energyX-ray absorptiometry) of the femoral neck and an US scanof the same bone district, acquiring both echographic imagesand unfiltered radiofrequency signals. US data wereanalyzed by a new algorithm that calculated the samediagnostic parameters obtained from DXA examination(BMD, T-score, Z-score). Accuracy of each parametercalculated by this algorithm was then evaluated through adirect comparison with DXA results as a function of bothpatient age and BMI. For 81.3% of the patients USdiagnosis (osteoporotic, osteopenic, healthy) coincided withthe corresponding DXA one and this accuracy level was notappreciably influenced by patient age nor by BMI. Theillustrated method has the potential to be used for routinepopulation screening programs for early osteoporosisdiagnosis and hip fracture prevention.

Autore Pugliese

Tutti gli autori

  • F. Chiriacò; F. Conversano; E. Quarta; L. Quarta; M. Muratore; A. Lay-Ekuakille; S. Casciaro

Titolo volume/Rivista

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Anno di pubblicazione

2014

ISSN

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ISBN

978-92-990073-5-8

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