Abstract

This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.

Autore Pugliese

• Carbone Luigi

Tutti gli autori

• Barreto A.C. H.; Santiago V.R.; Freire R.M.; Mazzetto S.E.; Denardin J.C.; Mele G.; Cavalcante I.M.; Ribeiro M.E. N. P.; Ricardo Nagila M. P. S.; Goncalves T.; Carbone L.; Lemos T.L. G.; Pessoa O.D. L.; Fechine P.B. A.

Titolo volume/Rivista

International journal of molecular sciences

Anno di pubblicazione

2013

ISSN

1422-0067

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile