Abstract

Prunus mahaleb L. is a marginal fruit crop producing cherry-like dark purple drupes with avery bitter taste, rich in polyphenolic compounds.A mahaleb fruit concentrated extract (mfce)has been assayed for its biological activities. In this work, we report results on the in vitroeffects of mfce including: i) anti-proliferative, gap junction intercellular communication (GJIC)modulation and pro-apoptotic properties in a breast cancer cell line (MCF-7), ii) antiinflammatoryproperties in human vascular endothelial cells (HUVEC), iii) anti-mutageniceffect on yeast Saccharomyces cerevisiae strain D7. Mfce exerted a dose-dependent antiproliferativeeffect on MCF-7 cells together with a significant time-dependent increase inGJIC and a pro-apoptotic effect. Furthermore, mfce significantly reduced levels of endothelialinflammatory antigens in a concentration-dependent manner. Finally, mfce protectedS. cerevisiae cells against H2O2 cytotoxicity by direct radical scavenging activity. This studydemonstrated multiple healthful biological effects of mfce, highlighting it as a potentialnutraceutical product.

Autore Pugliese

• Leone Antonella , Gerardi Carmela , Blando Federica , Mita Giovanni , Carluccio Maria Annunziata

Tutti gli autori

• Gerardi C.; Frassinetti S.; Caltavuturo L.; Leone A.; Lecci R.; Calabriso N.; Carluccio M.A.; Blando F.; Mita G.

Titolo volume/Rivista

Journal of Functional Foods

Anno di pubblicazione

2016

ISSN

1756-4646

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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