Abstract

Proteomic analysis shows that treatment of keratinocytes cultures with all trans retinoic acid (ATRA), under condition in which it inhibits cell growth, results in marked decrease of the level of the F1-beta subunit of the catalytic sector of the mitochondrial FoF1 ATP synthase complex. Enzymatic analysis shows in ATRA-treated keratinocytes a consistent depression of the ATPase activity, with decreased olygomycin sensitivity, indicating an overall alteration of the ATP synthase complex. These findings, together with the previously reported inhibition of respiratory complex I, show that depression of the activity of oxidative phosphorylation enzymes is involved in the cell growth inhibitory action of ATRA. (C) 2016 Elsevier Inc. All rights reserved.

Autore Pugliese

• Lippolis Rosa

Tutti gli autori

• Papa F.; Lippolis R.; Sardaro N.; Gnoni A.; Scacco S.

Titolo volume/Rivista

Biochemical and biophysical research communications

Anno di pubblicazione

2017

ISSN

0006-291X

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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