Abstract

Recent expansion of our knowledge on epigenetic changes strongly suggests that not only nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic modifications related to disease development, environmental exposure, drug treatment and aging. Thus, mtDNA methylation is attracting increasing attention as a potential biomarkerfor the detection and diagnosis of diseases and the understanding of cellular behaviour in particular conditions. In this paper we review the current advances in mtDNA methylation studies with particular attention to the evidences of mtDNAmethylation changes in diseases and physiological conditions so far investigated. Technological advances for the analysis of epigenetic variations are promising tools to provide insights into methylation of mtDNA with similar resolution levels as those reached for nDNA. However, many aspects related to mtDNA methylation are still unclear. More studies are needed to understand whether and how changes in mtDNA methylation patterns, global and gene specific, are associated to diseases or risk factors

Autore Pugliese

• Castegna Alessandra , Iacobazzi Vito

Tutti gli autori

• CASTEGNA A.;IACOBAZZI V.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2013

ISSN

1096-7192

ISBN

Non Disponibile

Numero di citazioni Wos

101

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

107

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile