Geographic population structure in Epstein-Barr Virus revealed by comparative genomics

Abstract

Epstein-Barr virus (EBV) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. We sequenced 27 complete EBV genomes from a cohort of Multiple Sclerosis (MS) patients and healthy controls from Italy, although no variants showed a statistically significant association with MS. Taking advantage of the availability of ~130 EBV genomes with known geographical origins, we reveal a striking geographic distribution of EBV sub-populations with distinct allele frequency distributions. We discuss mechanisms that potentially explain these observations, and their implications for understanding the association of EBV with human disease.


Tutti gli autori

  • D'ERCHIA A.M.;PICARDI E.;PESOLE G.

Titolo volume/Rivista

Non Disponibile


Anno di pubblicazione

2016

ISSN

1759-6653

ISBN

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Numero di citazioni Wos

7

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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