Abstract

New promising and versatile materials for the development of in situ sustained release systems consisting of thin films of either poly(2-hydroxyethyl methacrylate) or a copolymer based on poly(ethylene-glycol diacrylate) and acrylic acid were investigated. These polymers were electrosynthesized directly on titanium substrates and loaded with ciprofloxacin (CIP) either during or after the synthesis step. X-ray photoelectron spectroscopy was used to check the CIP entrapment efficiency as well as its surface availability in the hydrogel films, while high-performance liquid chromatography was employed to assess the release property of the films and to quantify the amount of CIP released by the coatings. These systems were then tested to evaluate the in vitro inhibition of methicillin-resistant Staphylococcus aureus (MRSA) growth. Moreover, a model equation is proposed which can easily correlate the diameter of the inhibition haloes with the amount of antibiotic released. Finally, MG63 human osteoblast-like cells were employed to assess the biocompatibility of CIP-modified hydrogel coatings.

Autore Pugliese

• Ceci Edmondo , De Giglio Elvira , Tantillo Giuseppina , Sabbatini Luigia

Tutti gli autori

• CECI E.;DE GIGLIO E.;TANTILLO G.;SABBATINI L.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2011

ISSN

1742-7061

ISBN

Non Disponibile

Numero di citazioni Wos

32

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

39

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile