Abstract

Glycyrrhiza glabra cultivation and harvesting produces substantial quantities of aerial parts as waste. With the aim to prospect an innovative valorization of these byproducts, the aerial parts were harvested in May and October and analyzed for their chemical profile, antioxidant properties, and effects on viability of five cancer cell lines. Pinocembrin was the main constituent. A significant protection of lipid peroxidation was observed with the May total extract (IC50 of 4.2 ± 0.4 μg/mL at 30 min of incubation). The effects on viability of HeLa, MCF-7, MDA-MB-231, Caco-2, and PC3 human cancer cells were investigated. All samples shown a remarkable activity with IC50 values below 25 μg/mL. Samples from plants harvested in May exhibited greater activity than those harvested in October. MCF-7 and HeLa were the most sensitive cells with IC50 in the range 2.73−3.01 and 3.28−5.53 μg/mL, respectively. G. glabra aerial parts represent a good source of valuable products.

Autore Pugliese

• Capobianco Loredana

Tutti gli autori

• F. Aiello , B. Armentano , N. Polera , G. Carullo , M.R. Loizzo , M. Bonesi , M.S. Cappello , L. Capobianco , R. Tundis

Titolo volume/Rivista

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anno di pubblicazione

2017

ISSN

0021-8561

ISBN

Non Disponibile

Numero di citazioni Wos

1

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

1

Ultimo Aggiornamento Citazioni

22/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile