Abstract

In the last years, several tissue engineering techniques have been applied to develop different kinds of osteochondral substitutes to overcome the scarce reparative properties of this tissue. The aim of this study was to generate and compare three biphasic scaffolds in an osteochondral lesion in a large-animal model. A critical osteochondral defect was generated in the medial femoral condyle of 18 skeletally mature sheep. Three defects were left untreated, the remaining lesions were divided into three groups: 5 lesions were treated with a biphasic scaffold made of collagen type I and small cylinders of Magnesium Hydroxyapatite; 5 lesions were treated with a biphasic substituted formed by collagen type I and Wollastonite, 5 lesions were treated with a scaffold made of collagen type I and small cylinders of Wollastonite/Hydroxyapatite. Animals were sacrificed after 3 months and samples were analyzed by CT and MRI, macroscopic evaluation and histology. Our study demonstrated that one of these novel biphasic scaffolds possesses the potential for being applied for one-stage procedures for osteochondral defects.

Autore Pugliese

• Sannino Alessandro , Gervaso Francesca , Scalera Francesca

Tutti gli autori

• Gervaso F. , Mangiavini L. , Di Giancamillo A. , Boschetti F. , Izzo D. , Zani D .D. , Di Giancamillo M. , Tessaro I. , Domenicucci M. , Scalera F. , Domeneghini C. , Crovace A .M. , Sannino A. , Peretti G .M.

Titolo volume/Rivista

JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS

Anno di pubblicazione

2016

ISSN

0393-974X

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

1

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile