Functionalized diarylisoxazoles inhibitors of ciclooxygenase

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Abstract

The present invention refers to isoxazole derivatives, in particular diarylisoxazole derivatives inhibitors of cyclooxygenase (COX), in particular cyclooxygenase-1 (COX-1), to their pharmaceutical compositions, the process for their preparation and their use for the chemoprevention and treatment of inflammatory syndromes and in the prevention and treatment of carcinomas, in particular intestinal, ovarian and cutaneous carcinomas, in the treatment of pain syndromes, in particular after surgery, and in the cardiovascular field as antithrombotics/vasoprotectives/cardioprotectives.

Classe Tecnologica

A - Human Necessities

Patent Office

United States Patent and Trademark Office

Numero Deposito

US7989450

Anno Deposito

2008

Anno Concessione

2009

Inventori Pugliesi

Tutti gli inventori

  • Antonio Scillimati
  • Paola Vitale
  • Leonardo Di Nunno
  • Paola Patrignani
  • Stefania Tacconelli
  • Marta Luciana Capone

Titolari pugliesi

Tutti i titolari

  • Università Degli Studi Di Bari Aldo Moro