Derivatives of 1,2,4-benzothiadiazine dioxide, their preparation and use as allosteric modulators of the AMPA receptor

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Abstract

A compound of formula I is described: which showed to be surprisingly and significantly effective as an allosteric modulator of the AMPA receptor and is therefore particularly suitable for the treatment of mnemocognitive disorders ascribable to an alteration of glutamatergic neurotransmission, such as age-related disorders, anxiety, progressive neurodegenerative disorders, depressive disorders, schizophrenia, obsessive-compulsive disorders and bipolar disorder.

Classe Tecnologica

A - Human Necessities

Patent Office

European Patent Office

Numero Deposito

EP2457906

Anno Deposito

2010

Anno Concessione

2012

Inventori Pugliesi

  • Carrozzo Marina Maria

Tutti gli inventori

  • Umberto Battisti
  • Giuseppe Cannazza
  • Giulia Puja
  • Marina Maria Carrozzo
  • Daniela Braghiroli
  • Carlo Parenti
  • Troisi Luigino
  • Jozwiak Krzysztof

Titolari pugliesi

Tutti i titolari

  • Università Del Salento