Abstract

Cell homeostasis results from the balance between cell capability to adapt or succumb to environmental stress. Mitochondria, inaddition to supplying cellular energy, are involved in a range of processes deciding about cellular life or death. The crucial role ofmitochondria in cell death is well recognized.Mitochondrial dysfunction has been associated with the death process and the onsetof numerous diseases. Yet, mitochondrial involvement in cellular adaptation to stress is still largely unexplored. Strong interestexists in pharmacologicalmanipulation ofmitochondrialmetabolism and signaling. The yeast Saccharomyces cerevisiae has provena valuablemodel organism in which several intracellular processes have been characterized in great detail, including the retrograderesponse to mitochondrial dysfunction and, more recently, programmed cell death. In this paper we review experimental evidencesof mitochondrial involvement in cytoprotection and propose yeast as a model system to investigate the role of mitochondria in thecross-talk between prosurvival and prodeath pathways.

Autore Pugliese

• Giannattasio Sergio

Tutti gli autori

• Zdralevic M.; Guaragnella N.; Antonacci L.; Marra E.; Giannattasio S.

Titolo volume/Rivista

The Scientific World Journal

Anno di pubblicazione

2012

ISSN

1537-744X

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile