Abstract

VLD (vive la difference) is a novel ab initio phasing approachthat is able to drive random phases to the correct values. Ithas been applied to small, medium and protein structuresprovided that the data resolution was atomic. It has neverbeen used for non-ab initio cases in which some phaseinformation is available but the data resolution is usually very ?far from 1 A. In this paper, the potential of VLD is tested forthe first time for a classical non-ab initio problem: molecularreplacement. Good preliminary experimental results encour-aged the construction of a pipeline for leading partialmolecular-replacement models with errors to refined solutionsin a fully automated way. The pipeline moduli and theirinteraction are described, together with applications to a wideset of test cases.

Autore Pugliese

• Mazzone Annamaria , Carrozzini Benedetta , Cascarano Giovanni Luca

Tutti gli autori

• Carrozzini B. ; Cascarano G.L. ; Comunale G. ; Giacovazzo C. ; Mazzone A.

Titolo volume/Rivista

Acta crystallographica. Section D, Biological crystallography.

Anno di pubblicazione

2013

ISSN

0907-4449

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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