Abstract

high-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers.OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs.METHOD: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, presence of hairpins, and validation by comparison with RNA sequencing datasets.RESULTS: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments.CONCLUSION: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.

Autore Pugliese

• Poltronieri Palmiro

Tutti gli autori

• Poltronieri P.; Sun B.; Huang K.Y.; Chang T.H.; Lee T.Y.

Titolo volume/Rivista

MicroRNA (Shariqah, United Arab Emirates)

Anno di pubblicazione

2018

ISSN

2211-5374

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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