Abstract

Purpose. The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to carotid intimamedia thickness (IMT), an index of atherosclerosis in human immunodeficiency virus (HIV)-1-infected patients.Methods. We enrolled 70 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months, in a prospective cohort study. Sonographically measured PRFT and carotid IMT, as well as serum metabolic parameters, were evaluated. PRFT and IMT were measured using 3.75-MHz convex and 7.5-MHz linear probes, respectively.Results. The mean PRFT and IMT in HIV-1-infected patients with visceral obesity was significantly greater than those in patients without it (p < 0.0001 and p < 0.01, respectively). Using the average IMT as the dependent variable in regression analysis, PRFT was an independent factor associated with carotid IMT (p < 0.05). A PRFT of 6.4 mm was the most discriminatory value for predicting an IMT >= 0.9 mm (sensitivity 83.3%, specificity 83.9%). Subjects with visceral obesity had a progressively increasing carotid IMT on the 12-month measurement (p < 0.05).Conclusion. Our data demonstrated that PRFT measurement could be used as an early predictor of IMT increase in HIV-1-infected patients receiving highly active antiretroviral therapy. (C) 2010 Wiley Periodicals, Inc. J Clin Ultrasound 38:190-195, 2010; Published online in Wiley InterScience (www.interscience.wiley. corn). DOI: 10.1002/jcu.20664

Autore Pugliese

• Zizza Antonella

Tutti gli autori

• P. Grima; M. Guido; A. Zizza; R. Chiavaroli

Titolo volume/Rivista

Journal of clinical ultrasound

Anno di pubblicazione

2010

ISSN

0091-2751

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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