Shades of red: comparative study on supercritical CO2 extraction of lycopene-rich oleoresins from gac, tomato and watermelon fruits and effect of the ?-cyclodextrin clathrated extracts on cultured lung adenocarcinoma cells' viability

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Abstract

Lycopene is a red carotenoid thought effective in preventingsome types of cancers and modulating immune and inflammatory responses.Though some fruits share the common feature of synthesizing and storinglycopene as main carotenoid within chromoplasts, they significantlydiffer in the lipophilic phytocomplex. The purpose of this work was: i)to extract solvent-free lycopene-rich oleoresins from gac, tomato andwatermelon ripe-fruits by supercritical CO2 suitable for functional foodand nutraceutical formulations; ii) characterize the oleoresins withrespect to carotenoids, tocochromanols, lipids, metals and antioxidantactivity; iii) prepare stable aqueous suspensions through oleoresinclathration into ?-cyclodextrins (?-CDs); iv) investigate the effect ofeach lycopene-containing suspension on viability of human lungadenocarcinoma cells.The results showed that all oleoresins represent a safe added-valuesource of lycopene characterized by high lipophilic antioxidant activity,improved by the synergy with other biomolecules. Interestingly, whenadministered at identical concentrations (0.5-10 ?M) of lycopene, theextracts showed conflicting behaviors: gac and tomato suspensionssignificantly increased cell viability, whereas watermelon oleoresin/?-CDsuspension significantly decreased cell viability. Although furtherstudies are required, this research suggests a fundamental role ofphytocomplex in affecting the responses of cancer cell survival to the invitro administration of lycopene.

Autore Pugliese

Tutti gli autori

  • Bruno A.; Durante M.; Marrese P.P.; Migoni D.; Laus M.; Pace E.; Pastore D.; Mita G.; Piro G.; Lenucci M.S

Titolo volume/Rivista

Journal of food composition and analysis

Anno di pubblicazione

2017

ISSN

0889-1575

ISBN

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