Abstract

IFN-induced depression is a suitable model for investigating vulnerability to depression. Weaimed at investigating the role of two vulnerability factors, life time mood disorder (LMD) and 5-HT-related gene polymorphisms in treated patients with infection by Hepatitis C Virus (HCV).Methods: Depressive symptoms of 130 consecutive HCV patients with no current psychopathology weremeasured during treatment with interferon and ribavirin. At baseline, LMD and 3 genotypes (5-HTTLPR, HTR1A, and TPH2) were also assessed.Results: Subgroups of43 patients with LMD, 96 with HTR1A-G allele, and 12 with both LMD and HTR1A-G homozygosity scored significantly higher to depression compared to the remaining patients duringAntiviral therapy. At the multiple regression analysis, LMD and HTR1A-G, whether separately or combined together, explained a similar amount of 10-22% of depression score variance, after controllingfor the associated variables(age and gender).Limitations: HCV patients referred to a tertiary care center are not representative of all patients withchronic hepatitis C. Mediating factors, including pro inflammatory cytokines and other potentiallyrelevant gene polymorphisms, could not be evaluated. Patients were not stratified by degree of liverinflammation. LMD diagnoses were not cross-checked with medical records and IFN-induced depressionwas measured with a self-report scale only.Conclusions: History of mood disorders and HTR1AG allele variation, the C-1019G polymorphism of thetranscriptional control region of the 5-HT1A receptor, independently predicted the incidence of IFN-induced depression in HCV patients, whether separately or jointly considered and although notreciprocally associated

Autore Pugliese

• Sonnante Gabriella

Tutti gli autori

• Cozzolongo R.; Porcelli P.; Cariola F.; Giannuzzi V.; Lanzilotta E.; Gentile M.; Sonnante G.; Leandro G.

Titolo volume/Rivista

Journal of affective disorders

Anno di pubblicazione

2015

ISSN

0165-0327

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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