Role of the probiotic strain Lactobacillus paracasei LMGP22043 carried by artichokes in influencing faecal bacteria and biochemical parameters in human subjects.

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Abstract

To evaluate the positive influence of the probiotic strain Lactobacillusparacasei LMGP22043 carried by artichokes into the human gut with specialreference to faecal bacterial balance, short-chain fatty acid concentrations andenzyme activities in a randomized, double-blind human trial in comparisonwith probiotic-free artichokes (control).Methods: Twenty subjects were randomized into two groups, which consumeddaily 180 g of the artichoke product (probiotic or control) during two 15-daystudy periods (periods 1 and 2) separated by a 15-day washout in a crossovermanner. Faecal samples were subjected to microbiological and biochemicalanalyses, and a strain-specific PCR was performed to monitor the probioticstrain.Results: The probiotic strain, transported by the vegetable matrix, transientlycolonized the gut of 17 D 20 subjects (median 6Æ87 log CFU g)1 faeces), antagonizedEscherichia coli and Clostridium spp. and increased the genetic diversityof lactic population based on REP-PCR profiles, mainly after period 1.Conclusions: The probiotic L. paracasei LMGP22043 successfully colonizedthe human gut and positively influenced faecal bacteria and biochemicalparameters.Significance and Impact of the Study: The association of the probiotic L. paracaseiwith a food carrier rich in fibre can represent a new strategy for favouringa daily supply of probiotics and attracting more consumers to vegetable food fortified with probiotic strains.

Autore Pugliese

Tutti gli autori

  • Valerio F.; De Candia S.; Lonigro S.L.; Russo F.; Riezzo G.; Orlando A.; De Bellis P.; Sisto A.; Lavermicocca P.

Titolo volume/Rivista

Journal of applied microbiology

Anno di pubblicazione

2011

ISSN

1364-5072

ISBN

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