Abstract

In this paper we studied the in vivo neoadjuvant Androgen Deprivation Therapy (ADT) effect on theexpression of TGF-b1 and its receptor Tb-RII. Mechanisms of androgen dependence are critical to understandingprostate cancer progression to androgen independence associated with disease mortality, andTGF-b is thought to support prostatic apoptosis as its expression coincides with androgen ablation inbenign and cancer tissues.Increase of both mRNA and protein level were shown for the first time only in the patients who underwentneoadjuvant ADT for 1-month. This transient increase of TGF-b expression after androgen ablationsuggested cooperation of the pathways in prostate regression. Since no alteration was observed in thegene transcriptional activity, the molecular mechanism of this cooperation, probably act at the post-transcriptionallevel.TGF-b1 and Tb-RII specific signals were co-localized within the neoplastic prostate epithelium. Ourresults suggests that the androgens deprivation by means of ADT for 1-month, involves a shift of theTGF-b1 mechanism in prostate cancer, suggesting that the TGF-b1 promotes prostate epithelial cell proliferationand inhibits apoptosis in a autocrine way.

Autore Pugliese

• Perlino Elda

Tutti gli autori

• P. Fuzio ; P. Ditonno ; M. Rutigliano ; M. Battaglia ; C. Bettocchi ;A. Loverre ; G. Grandaliano ; E. Perlino

Titolo volume/Rivista

Cancer letters

Anno di pubblicazione

2012

ISSN

0304-3835

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile