Abstract

The nanoscale structural order of air-dried rat-tail tendon is investigated using small-angle X-ray scattering (SAXS). SAXS fiber diffraction patterns were collected with a superbright laboratory microsource at XMI-LAB [Altamura, Lassandro, Vittoria, De Caro, Siliqi, Ladisa & Giannini (2012). J. Appl. Cryst. 45, 869-873] for increasing integration times (up to 10 h) and a novel algorithm was used to estimate and subtract background, and to deconvolve the beam-divergence effects. Once the algorithm is applied, the peak visibility improves considerably and reciprocal space information up to the 22nd diffraction order is retrieved (q = 0.21 angstrom(-1), d = 29 angstrom) for an 8-10 h integration time. The gain in the visibility is already significant for patterns collected for 0.5 h, at least on the more intense peaks. This demonstrates the viability of detecting structural changes on a molecular/nanoscale level in tissues with state-of-the-art laboratory sources and also the technical feasibility to adopt SAXS fiber diffraction as a future potential clinical indicator for disease.

Autore Pugliese

• Giannini Cinzia , Altamura Davide , Siliqi Dritan , De Caro Liberato , Sibillano Teresa

Tutti gli autori

• De Caro L.; Altamura D.; Sibillano T.; Siliqi D.; Filograsso G.; Bunk O.; Giannini C.

Titolo volume/Rivista

Journal of applied crystallography

Anno di pubblicazione

2013

ISSN

0021-8898

ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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