Abstract

A fundamental issue in biomedical and environmental sciences is the development of sensitive and robust sensors able to probe the analyte of interest, under physiological and pathological conditions or in environmental samples, and with very high spatial resolution. In this work, novel hybrid organic fibers that can effectively report the analyte concentration within the local microenvironment are reported. The nanostructured and flexible wires are prepared by embedding fluorescent pH sensors based on seminaphtho-rhodafluor-1-dextran conjugate. By adjusting capsule/polymer ratio and spinning conditions, the diameter of the fibers and the alignment of the reporting capsules are both tuned. The hybrid wires display excellent stability, high sensitivity, as well as reversible response, and their operation relies on effective diffusional kinetic coupling of the sensing regions and the embedding polymer matrix. These devices are believed to be a powerful new sensing platform for clinical diagnostics, bioassays and environmental monitoring. Novel pH-sensing organic fibers are prepared by capsule-based sensors. Appropriate choice of capsule loading during electrospinning ensures alignment within the fibers, leading to pH-sensing devices with excellent stability, high sensitivity, ?m-spatial resolution as well as reversible response to proton switches. These results show a promising strategy for the development of sensitive and robust self-reporting fiber-optic sensors for bioassays and environmental monitoring.

Autore Pugliese

• Del Mercato Loretta Laureana

Tutti gli autori

• Del Mercato L.L.; Moffa M.; Rinaldi R.; Pisignano D.

Titolo volume/Rivista

Small

Anno di pubblicazione

2015

ISSN

1613-6810

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

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Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile