Abstract

We have developed an integrated microfluidic platform for producing 2-[F-18]-fluoro-2-deoxy-D-glucose(F-18-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40-80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.

Autore Pugliese

• Arima Valentina

Tutti gli autori

• Arima V. ; Pascali G. ; Lade O. ; Kretschmer H. R. ; Bernsdorf I. ; Hammond V. ; Watts P. ; De Leonardis F. ; Tarn M.D.; Pamme N. ; Cvetkovic B.Z. ; Dittrich P. S. ; Vasovic N. ; Duane R. ; Jaksic A. ; Zacheo A. ; Zizzari A. ; Marra L.; Perrone E. ; Salvadori P. A. ; Rinaldi R.

Titolo volume/Rivista

Lab on a chip

Anno di pubblicazione

2013

ISSN

1473-0197

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile