Abstract

Proteomics, the large scale study of proteins and protein variations, contributes to a better understanding of themolecular basis of variability in susceptibility to diseases that are associated with genetic diversity and environmentalfactors. The development of proteomic technologies has permitted the unprecedented large-scale identification ofproteins in any biological system. Human proteomics point out physiological conditions that could greatly impact onmedicine. This knowledge has the potential to decode the pathogenic mechanisms underlying diseases, elucidatepotential risk factors and molecular targets for drug development and therapeutic interventions and identify promisingbiomolecules that could be developed for diagnostic and prognostic purposes and for improved disease managementstrategies. Thus proteomics can translate basic scientific discoveries into the clinical practice for precision medicine.This report provides an overview of targeted proteomics in biomedical clinical science by focusing on current stateof-the-art relatively to advances in biomedical proteomic applications. Future prospective metaproteomics andproteogenomics studies are highlighted.

Autore Pugliese

• Lippolis Rosa

Tutti gli autori

• R. Lippolis; M. De Angelis

Titolo volume/Rivista

Journal of proteomics and bioinformatics

Anno di pubblicazione

2016

ISSN

0974-276X

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile