Abstract

Vascular inflammation, especially at the level of endothelial cells, has been shown to play a pivotal role in theinception, progression, and clinical complications of atherosclerosis. The common denominators for the activationof inflammatory genes appear to be a small subset of transcription factors--among which include nuclear factor-?B,activator protein-1 (AP-1), and GATA--that function as the central hub of vascular inflammation. Strategies directedto inhibit both the secondary mediators and the primary triggers (atherosclerosis risk factors) appear viable to inhibitatherosclerosis. However, attempts have now been made to address the central hub of vascular inflammation. "Old"drugs, such as dipyridamole, can also now be revisited for properties related to inhibition of vascular inflammation,probably by acting on the common hub of inflammation.

Autore Pugliese

• Scoditti Egeria , Carluccio Maria Annunziata , Massaro Marika

Tutti gli autori

• De Caterina R.; Massaro M.; Scoditti E.; Carluccio M.A.

Titolo volume/Rivista

Annals of the New York Academy of Sciences

Anno di pubblicazione

2010

ISSN

0077-8923

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile