Abstract

Mitophagy is an essential process that maintains mitochondrial quality and number, thus limiting cellular degeneration. Along with apoptosis, mitophagy participates in cellular fate decisions by eliminating damaged mitochondria. A variety of mitochondrial parameters, such as structure, membrane potential, and reactive oxygen species, are key determinants in triggering the mitophagic machinery. These parameters are also important regulators of the mitochondrial capacity for calcium (Ca 2+) uptake. Rapid Ca 2+ accumulation in the mitochondrial matrix allows for prompt stimulation of the organelle. This process requires a close morphofunctional coupling between mitochondria and the main intracellular Ca 2+ stores. In mitophagy, the role of Ca 2+ remains obscure. What role does mitochondrial Ca 2+ play in metabolic sensing or in mitochondrial remodeling? Is endoplasmic reticulum (ER)-Ca 2+ crosstalk involved? These are some of the questions that we address in this review.

Autore Pugliese

• Lasorsa Francesco Massimo

Tutti gli autori

• Rimessi A.; Bonora M.; Marchi S.; Patergnani S.; Marobbio C.M.; Lasorsa F.M.; Pinton P.

Titolo volume/Rivista

Autophagy

Anno di pubblicazione

2013

ISSN

1554-8627

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile