Abstract

The behavior of cells in terms of cell-substrate and cell-cell interaction is dramatically affected by topographicalcharacteristics as shape, height, and distance, encountered in their physiological environment. The combinationof chemistry and topography of a biomaterial surface influences in turns, important biological responses asinflammatory events at tissue-implant interface, angiogenesis, and differentiation of cells. By disentangling theeffect of material chemistry from the topographical one, the possibility of controlling the cell behavior can beprovided. In this paper, surfaces with different roughness and morphology were produced by radiofrequency (RF,13.56 MHz) glow discharges, fed with hexafluoropropylene oxide (C3F6O), in a single process. Coatings withdifferent micro/nanopatterns and the same uppermost chemical composition were produced by combining twoplasma deposition processes, with C3F6O and tetrafluoroethylene (C2F4), respectively. The behavior of osteoblastlikecells toward these substrates clearly shows a strict dependence of cell adhesion and proliferation on surfaceroughness and morphology.

Autore Pugliese

• Sardella Eloisa , Gristina Roberto , Ingrosso Chiara

Tutti gli autori

• Intranuovo F.; Favia P.; Sardella E; Ingrosso C.; Nardulli M.; d'Agostino R.; Gristina R.

Titolo volume/Rivista

Biomacromolecules

Anno di pubblicazione

2011

ISSN

1525-7797

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

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Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile