Abstract

In this review we would like to aim at pharmaceuticals engineered on the nanoscale, i.e. pharmaceuticals where the nanomaterial plays the pivotal therapeutic role or adds additional functionality to the previous compound. Those cases would be considered as nanopharmaceuticals. The development of inorganic systems is opening the pharmaceutical nanotechnology novel horizons for diagnosis, imaging and therapy mainly because of their nanometer-size and their high surface area to volume ratios which allow for specific functions that are not possible in the micrometer-size particles. This review will focus on pharmaceutical forms that are based on inorganic nanoparticles where the nanosize of the inorganic component provides unique characteristics to the pharmaceutical form. Several examples of these systems that are either in pre-clinical investigation and under examination by the Food and Drug Administration (FDA) or that have been already approved by the FDA and are in clinical practice today like Gastromark (R), NanoTherm (R), Colloidal Gold for Lateral Flow tests, HfO-NPs, BioVant (TM) will be described and reviewed. (c) 2010 Elsevier Ltd. All rights reserved.

Autore Pugliese

• Del Mercato Loretta Laureana

Tutti gli autori

• Rivera Gil P.; Huehn D.; Del Mercato L.L.; Sasse D.; Parak W.J.

Titolo volume/Rivista

Pharmacological research

Anno di pubblicazione

2010

ISSN

1043-6618

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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