Abstract

Positive-strand RNA [(+)RNA] viruses constitute the largest class of infectious agents causing major plant, animal and human diseases. (+)RNA viruses share common replication mechanisms; in particular, a highly conserved feature is the association of the genome replication with host cell membrane structures derived from the endoplasmic reticulum (ER) (picornaviruses, potyviruses, comoviruses, nepoviruses and bromoviruses) or from the limiting membrane of organelles such as lysosomes or endosomes (alphaviruses), vacuoles (cucumoviruses), mitochondria (nodaviruses, some tombusviruses, carmoviruses, ampeloviruses and maculaviruses), peroxisomes (several tombusviruses) and chloroplasts (tymoviruses and some marafiviruses). Virus-encoded proteins are responsible for the intracellular localization of the viral replication complex. Cell membranes are modified to form vesicular structures in which virus replication takes place, protected from degradation of host ribonucleases and recognition of host defence reactions. Vesiculation of the target cellular membrane in natural hosts and in the yeast Saccharomyces cerevisisae, an alternative model host for studying virus replication, is well documented for nodaviruses (animal viruses) and bromo- and tombusviruses (plant viruses). An overview of virus-induced cell membrane modifications in plant and yeast cells will be given.

Autore Pugliese

• Rubino Luisa

Tutti gli autori

• Rubino L.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2015

ISSN

Non Disponibile

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile