Abstract

Multicopper oxidases (MCOs), such as ascorbic acid oxidase and ceruloplasmin,are multidomain proteins capable of oxidizing many structurally unrelated compoundsreducing oxygen to water without ever generating reactive oxygen species. WhileMCOs show great oxidative versatility, they can only transfer electrons to molecularoxygen, which is the obligate electron acceptor. Therefore, MCOs could also be consideredas ''O2 consuming enzymes'', thus contributing to create those states of hypoxia that arenormally found in tissues, cells and cell compartments. Since hypoxia is also a commonfeature of many rapidly growing solid tumors, we postulate that the regulation ofGPI-ceruloplasmin isoform, present on the surface of the plasma membrane, could bethe molecular event in the creation and the maintenance of hypoxia in tumor cells.By silencing the different MCO genes with siRNA, it would appear possible to attempt toovercome tumor hypoxia, thus improving the efficiency of radiotherapy.

Autore Pugliese

• Arrigoni Roberto

Tutti gli autori

• Arrigoni R.; Arrigoni O.

Titolo volume/Rivista

Atti della Accademia Nazionale dei Lincei. Rendiconti Lincei. Scienze fisiche e naturali

Anno di pubblicazione

2010

ISSN

1720-0776

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile