Abstract

The aim of this study is to investigate the effect of a non-invasive physical treatment on activated microglia of a well-established mouse model of Parkinson disease (PD), based on intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To this aim, we proposed a Radio electric asymmetric conveyer (REAC) technology, with its specific therapeutic protocols of regenerative medicine: tissue optimization - regenerative (TO-RGN), as an innovative therapeutic strategy for the treatment of PD. We observed that REAC TO-RGN exposition can attenuate the damage of nigrostriatal pathway induced by MPTP treatment in mice, decreasing levels of pro-inflammatory mediators in the substantia nigra pars compacta (SNpc) of MPTP-mice. Besides, TH immunostaining in MPTP-treated mice exposed to REAC TO-RGN resulted more pronounced in both substantia nigra and striatum in comparison to animals that received only MPTP treatment. Overall, these data suggest that REAC TO-RGN treatment can have neuroprotective effects in MPTP-induced PD mice model, which may be related to reduced inflammatory reaction.

Autore Pugliese

• Aloisi Alessandra

Tutti gli autori

• Panaro M.A.; Aloisi A.; Nicolardi G.; Lofrumento D.; De Nuccio F.; La Pesa V.; Carofiglio V.; Rinaldi R.; Calvello R.; Fontani V.; Rinaldi S.

Titolo volume/Rivista

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Anno di pubblicazione

2015

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ISBN

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Numero di citazioni Wos

Nessuna citazione

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Settori ERC

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