Major osteoporotic fragility fractures: Risk factor updates and societal impact

Abstract

Osteoporosis is a silent disease without any evidenceof disease until a fracture occurs. Approximately 200million people in the world are affected by osteoporosisand 8.9 million fractures occur each year worldwide.Fractures of the hip are a major public health burden,by means of both social cost and health condition ofthe elderly because these fractures are one of the maincauses of morbidity, impairment, decreased quality oflife and mortality in women and men. The aim of thisreview is to analyze the most important factors relatedto the enormous impact of osteoporotic fractures onpopulation. Among the most common risk factors, lowbody mass index; history of fragility fracture, environmentalrisk, early menopause, smoking, lack of vitaminD, endocrine disorders (for example insulin-dependentdiabetes mellitus), use of glucocorticoids, excessivealcohol intake, immobility and others represented themain clinical risk factors associated with augmentedrisk of fragility fracture. The increasing trend of osteoporosisis accompanied by an underutilization of theavailable preventive strategies and only a small numberof patients at high fracture risk are recognized andsuccessively referred for therapy. This report providesanalytic evidences to assess the best practices inosteoporosis management and indications for theadoption of a correct healthcare strategy to significantlyreduce the osteoporosis burden. Early diagnosis is thekey to resize the impact of osteoporosis on healthcaresystem. In this context, attention must be focused onthe identification of high fracture risk among osteoporoticpatients. It is necessary to increase nationalawareness campaigns across countries in order toreduce the osteoporotic fractures incidence.


Tutti gli autori

  • P. Pisani; M.D. Renna; F. Conversano; E. Casciaro; M. Di Paola; E. Quarta; M. Muratore; S. Casciaro

Titolo volume/Rivista

World journal of orthopedics


Anno di pubblicazione

2016

ISSN

2218-5836

ISBN

Non Disponibile


Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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