Abstract

Advanced hepatocellular carcinoma (HCC) is a clinical challenge with limited treatment options. The orally activemultikinase inhibitor sorafenib is the only anticancer agent showing a survival benefit in these patients.As well as significant activity, sorafenib is characterized by severe toxic side effects limiting the possible therapeuticresponse (1). Nanoparticle (NP) based approaches offer a valuable alternative for cancer drug delivery,thus ensuring the accumulation of high concentrations of drug to the targeted cancer cell, with a concomitantreduced toxicity of normal tissue. Superparamagnetic iron oxide NPs (SPIONs) are very attractive for deliveryof therapeutic agents as they have been reported to enhance the drug delivery to specific locations in thebody through the application of an external magnetic field (2). Here, solid lipid NPs (SLNs) containing sorafeniband SPIONs have been prepared by a hot homogenization technique using cetyl palmitate as lipid matrix andpolyethylene glycol modified phospholipids (PEG lipids), in order to achieve a PEG-based anti-fouling coating onSLN surface. These nanoformulations, thoroughly investigated by means of complementary techniques, havefinally resulted effective drug delivery magnetic nanovectors with good stability in aqueous medium and highdrug encapsulation efficiency. In addition, the relaxometric characterization has proven that the magnetic SLNloaded with sorafenib are also very efficient contrast agents, with a great potential in magnetic resonance imagingtechnique. The proposed magnetic SLNs loaded with sorafenib represent promising candidates for imageguided and magnetic targeting of sorafenib to liver towards an efficacious treatment of HCC.

Autore Pugliese

• Striccoli Marinella , Depalo Nicoletta

Tutti gli autori

• N. Depalo; F. Vischio; I. Arduino; S. Villa; F. Canepa; E. Fanizza; B. Chul Lee; V. Laquintana; A. Lopedota; A. Cutrignelli; M.P. Scavo; M. Striccoli; A. Agostiano; M.L. Curri; N. Denora

Titolo volume/Rivista

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Anno di pubblicazione

2017

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Numero di citazioni Wos

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Settori ERC

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