Abstract

In the field on nanomedicine, superparamagnetic nanoparticles are one of the moststudied nanomaterials for theranostics. In this paper, a one-pot synthesis of magneticnanoparticles is presented, with elevated control on particles size from 10 to 40 nm. Themonitoring of vacuum level is here introduced as a crucial parameter for achieving a fine particlemorphology. Magnetic properties of these nanoparticles are highly affected by disorders ormismatches in crystal structure. A prolonged oxidation step is applied to the obtainednanoparticles to transform the magnetic phases into a pure maghemite one, confirmed by a highresolution XPS analysis, by Mössbauer spectrometry and, indirectly, by increased performancesin magnetization curves and in relaxation times. Afterward, the attained nanoparticles aretransferred in water by a non-derivatized dextran coating. The thermogravimetric analysisconfirms that the polysaccharide molecules replace the oleic acid on the surface by stabilizingthe particles in aqueous phase and culture media. Preliminary in vitro test reveals as the dextrancoated nanoparticles are not passively internalized from the cells. As proof of concept, asecondary layer of chitosan assures a positive charge to the nanoparticle surface, thus enhancingthe cellular internalization.

Autore Pugliese

• Aloisi Alessandra

Tutti gli autori

• R. Di Corato; A. Aloisi; S. Rella; J.-M. Greneche;G. Pugliese; T. Pellegrino; C. Malitesta;R. Rinaldi

Titolo volume/Rivista

ACS applied materials & interfaces

Anno di pubblicazione

2018

ISSN

1944-8252

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile