Abstract

Nanoparticles (NPs) are emerging as a potential medical tool for novel diagnostic, drug delivery, and therapeutic approaches. Among them, a spherical NP with a core-shell structure is a way to combine multiple functionalities on the nanoscale. In this paper, we describe the preparation characterization and applications of core-shell iron oxide-gold nanoparticles (Fe3O 4@Au NPs). A comprehensive set of experiments, including transmission electron microscopy, dynamic light scattering, small angle neutron scattering, and ultraviolet visible spectroscopy is applied to characterize their chemical, physical, and optical properties. We also study their applicability as contrast agents for magnetic resonance imaging (MRI): the measurement of longitudinal and transverse relaxation times of Fe3O4@Au NPs in vitro and in vivo allowed the assessment of longitudinal (R1) and transverse (R2) relaxivities at 1.5 and 3 T. Finally, a procedure for functionalizing NPs with integrin targeting cyclic Arginine-Glycine-Aspartate peptidomimetic is reported, leading to the development of nanoscale probes for ?v?3 integrin, particularly attractive in terms of resolution and 3-D imaging capabilities. The resulting multifunctional nanoprobes offer suitable blood-circulation time and contrast for microimaging as well as for gradient-echo MRI, and could enable new imaging magnetoplasmonic applications.

Autore Pugliese

• Conversano Francesco , Casciaro Sergio

Tutti gli autori

• L. Menichetti; L. Manzoni; L. Paduano; A. Flori; C. Kusmic; D. De Marchi; S. Casciaro; F. Conversano; M. Lombardi; V. Positano; D. Arosio

Titolo volume/Rivista

IEEE sensors journal

Anno di pubblicazione

2013

ISSN

1530-437X

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile