Abstract

Fourteen metabolites, isolated from phytopathogenic and toxigenic fungi, were evaluated for their in vitro antigrowthactivity for six distinct cancer cell lines, using the MTT colorimetric assay. Bislongiquinolide (1) and dihydrotrichodimerol(5), which belong to the bisorbicillinoid structural class, displayed significant growth inhibitory activity against the sixcancer cell lines studied, while the remaining compounds displayed weak or no activity. The data show that 1 and 5have similar growth inhibitory activities with respect to those cancer cell lines that display certain levels of resistanceto pro-apoptotic stimuli or those that are sensitive to apoptosis. Quantitative videomicroscopy analysis revealed that 1and 5 exert their antiproliferative effect through cytostatic and not cytotoxic activity. The preliminary results from thecurrent study have stimulated further structure-activity investigations with respect to the growth inhibitory activity ofcompounds belonging to the bisorbicillinoid group.

Autore Pugliese

• Altomare Claudio , Vurro Maurizio

Tutti gli autori

• Saidou Balde E.; Andolfi A.; Bruyère C.; Cimmino A.; Lamoral-Theys D.; Vurro M.; Van Damme M.; Altomare C.; Mathieu V.; Kiss R.; Evidente A.

Titolo volume/Rivista

Journal of natural products

Anno di pubblicazione

2010

ISSN

0163-3864

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

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Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile