Abstract

It is becoming apparent that spatio-temporally controlled patterns of DNA methylation and histonemodifications ensure that each cell in the body gets differentiated into its required cell fate during normaldevelopment. It is a well-coordinated and tightly synchronized unidirectional process that involves stepwisegene silencing associated with developmental stages, as well as the activation of tissue-specificprogramming of genes. However, dysregulations in epigenetic modifications can severely disturb normaldevelopmental pathways, thus leading to cancer development and progression. Furthermore, increasing listsof research publications are examining tumor suppressor and oncogenic miRNAs, which are epigeneticallymodified in different cancers, as well as upregulated long non-coding RNAs acting as miRNA sponges.

Autore Pugliese

• Poltronieri Palmiro

Tutti gli autori

• Farooqi A.; Fuentes-Mattei E.; Fayyaz S.; Goblirsch M.; Raj P.; Poltronieri P.; Calin G.

Titolo volume/Rivista

Seminars in cancer biology

Anno di pubblicazione

2019

ISSN

1044-579X

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile