Abstract

Biosystems integration into an organic field-effect transistor (OFET)structure is achieved by spin coating phospholipid or protein layersbetween the gate dielectric and the organic semiconductor. Anarchitecture directly interfacing supported biological layers to theOFET channel is proposed and, strikingly, both the electronic propertiesand the biointerlayer functionality are fully retained. Theplatform bench tests involved OFETs integrating phospholipids andbacteriorhodopsin exposed to 1-5% anesthetic doses that revealdrug-induced changes in the lipid membrane. This result challengesthe current anesthetic action model relying on the so far providedevidence that doses much higher than clinically relevant ones(2.4%) do not alter lipid bilayers' structure significantly. Furthermore,a streptavidin embedding OFET shows label-free biotin electronicdetection at 10 parts-per-trillion concentration level, reachingstate-of-the-art fluorescent assay performances. These examplesshow how the proposed bioelectronic platform, besides resultingin extremely performing biosensors, can open insights into biologicallyrelevant phenomena involving membrane weak interfacialmodifications.

Autore Pugliese

• Giannini Cinzia , Altamura Davide , Mallardi Antonia

Tutti gli autori

• Angione M.D.; Cotrone S.; Magliulo M.; Mallardi A.; Altamura D.; Giannini C.; Cioffi N.; Sabbatini L.; Fratini E.; Baglioni P.; Scamarcio G.; Palazzo G.; Torsi L.

Titolo volume/Rivista

Proceedings of the National Academy of Sciences of the United States of America

Anno di pubblicazione

2012

ISSN

0027-8424

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile