Inorganic Nanoparticles for Theranostic Applications: State of the Art Review and Main Future Perspectives

Abstract

Over the last decade many research efforts havebeen devoted to the development of combined diagnostic andtherapeutic (theranostic) nanosystems for targeted diagnoses andself-tailored treatments of various diseases, especially in theoncologic field. These nanoplatforms are expected to offer greatopportunities in personalized medicine, which represents the nextfuture of patient care. The most promising candidates as targetedtheranostic agents are based on specific inorganic nanoparticles(NPs) such as superparamagnetic iron oxide NPs, quantum dots,silica nanospheres, gold nanorods and halloysite nanotubes. Thepresent paper provides an overview of the current state of the artin the development of inorganic NPs that can simultaneously actas both contrast agents for non-ionizing cellular imagingtechniques and as therapeutic agents, highlighting their potentialstrengths and critical aspects in view of an actual clinicaltranslation. The most realistic perspectives of personalizedmedicine based on nanosized theranostic agents are also outlined,taking into account both the associated challenges and thecorresponding opportunities.


Autore Pugliese

Tutti gli autori

  • Casciaro S.

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Anno di pubblicazione

2015

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Settori ERC

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