Abstract

An in vitro investigation based on QuantitativeUltrasound (QUS) has been carried out in this paper on asample of human femoral head, aiming at microstructurecharacterization and bone quality assessment. Two QUSparameters, Integrated Reflection Coefficient (IRC) andApparent Integrated Backscatter (AIB) were measured byaccurately analyzing ultrasonic signals backscattered fromthe target bone when immersed in water and insonified at2.25 MHz. In particular, US data were acquired from 22different positions along the maximum sectionperpendicular to the axial direction (head-neck axis) of thetarget sample. The obtained data were compared with localstructural properties gathered at each considered positionfrom a high-resolution micro-computed tomography(microCT) scan of the same sample. A linear regressionanalysis showed an appreciable correlation between QUSparameters and some of the micro-structural parameters. Asexpected, IRC correlated better with cortical bone volumefraction (r = -0.53), and AIB with trabecular bone volumefraction (r = -0.60) and trabecular spacing (r = 0.47). Theseresults are particularly encouraging in view of a possibleclinical translation of the proposed approach for earlyosteoporosis diagnosis.

Autore Pugliese

• Conversano Francesco , Casciaro Sergio

Tutti gli autori

• M. Peccarisi; T. De Marco; L. Spedicato; A. Greco; F. Conversano; D. Panetta; G. Guido; V. Bottai; P. Salvadori ; S. Casciaro

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2014

ISSN

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ISBN

978-92-990073-5-8

Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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