Abstract

The aim of this study was to investigate the relationships between selected quantitative ultrasound (QUS)parameters and human femur microstructure properties, as quantified by micro-computed tomography (micro-CT). Theauthors employed an innovative custom-designed experimental set-up, which allowed the insonification of eachportion of an excised femoral head sample, simultaneously including trabecular region, cortical layer and cartilage intheir physiologic morphological configuration. Thirty different, uniformly distributed, regions of interest were analysedfor the calculation of apparent integrated backscatter (AIB), integrated reflection coefficient (IRC) and several micro-CTparameters. QUS data acquisitions were performed through both single-element ultrasound transducers at twodifferent frequencies (2.25 and 3.5 MHz) and a clinically available 128-element echographic probe. Obtained resultsshowed that AIB was strongly correlated with trabecular network properties (r up to 0.80) and IRC had appreciablelinear correlations with cortical bone density (r up to 0.57). The agreement between single-element transducers andechographic probe, combined with the innovative approach of considering the entire femoral head in its physiologicalshape with all its components (cartilage, cortical layer, trabecular region), encourages the clinical translation of theproposed approach as a possible new method for early osteoporosis diagnosis.

Autore Pugliese

• Conversano Francesco , Casciaro Sergio

Tutti gli autori

• M. Peccarisi; T. De Marco; F. Conversano; P. Pisani; L. Spedicato; A. Greco; D. Panetta; G. Guido; V. Bottai; P.A. Salvadori.

Titolo volume/Rivista

IET science, measurement & technology

Anno di pubblicazione

2016

ISSN

1751-8822

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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