In vitro stability of Cucumber mosaic virus nanoparticles carrying aHepatitis C virus-derived epitope under simulated gastrointestinal conditions and in vivo efficacy of an edible vaccine

Abstract

The Cucumber mosaic virus (CMV) is an isodiametric plant virus with an extremely wide host range, present worldwide. CMV chimeric particles (R9-CMV), engineered to express a 27-aa synthetic peptide derived from Hepatitis C virus (HCV), were demonstrated to be stable under simulated gastric and intestinal conditions. Then the possibility of inducing a humoral immune response in rabbits fed with R9-CMV infected lettuce plants was demonstrated, suggesting that this system could function as a confirming tool of a bioreactor for the production of a stable edible vaccine against HCV.


Autore Pugliese

Tutti gli autori

  • M. Nuzzaci; A. Vitti; V. Condelli; M.T. Lanorte; C. Tortorella; D. Boscia; P. Piazzolla; G. Piazzolla

Titolo volume/Rivista

Journal of virological methods


Anno di pubblicazione

2010

ISSN

0166-0934

ISBN

Non Disponibile


Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile