Abstract

Halloysite Clay nanotubes (HNTs) are naturallyoccurring nanomaterials composed of double layeredaluminosilicate minerals with a hollow tubular structure. Due totheir interesting structural characteristics, chemically activeexternal and internal surfaces, cheap and abundant availability,HNTs have recently become the subject of research attention as anew type of material for various biological applications, includingdrug and gene delivery vehicles, cancer cells isolation, boneimplants, ultrasound contrast agents, cancer and stem cellsisolation and cosmetics. Therefore, assessment of HNTbiocompatibility has gained importance to demonstrate itssuitability for clinical purposes. In this study, HNTs were denselycoated with poly(ethylene glycol) (PEG) and MTT measurementswere carried out on two different human cancer cell lines, namelyHeLa (cervical cancer) cells and HepG2 (hepatocarcinoma) cells,to quantify the biocompatibility of PEG-coated HNTs as afunction of nanotube dosage and incubation time. While noncoatednanotubes exhibited significant concentration- and timedependenttoxicity, PEG-coated HNTs resulted fullybiocompatible for concentrations up to 0.5 mg/mL and forincubation time up to 72 h, making them suitable candidates fornanomedicine applications.

Autore Pugliese

• Conversano Francesco , Di Paola Marco , Casciaro Sergio , Leporatti Stefano

Tutti gli autori

• M. Di Paola; P. Pisani; F. Conversano; E.A. Sbenaglia; S. Leporatti; S. Casciaro.

Titolo volume/Rivista

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Anno di pubblicazione

2015

ISSN

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ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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