Abstract

Despite the growing literature about diphenylalanine-based peptide materials, it still remains a challenge to delineate the theoretical insight into peptide nanostructureformation and the structural features that could permit materials with enhanced properties to be engineered. Herein, we report the synthesis of a novel peptide building blockcomposed of six phenylalanine residues and eight PEG units, PEG8-F6. This aromatic peptide self-assembles in water in stable and well-ordered nanostructures with optoelectronic properties. A variety of techniques, such as fluorescence, FTIR, CD, DLS, SEM, SAXS, and WAXS allowed us to correlate the photoluminescence properties of the self-assembled nanostructures with the structural organization of the peptide building block at the micro- and nanoscale. Finally, a model of hexaphenylalanine in aqueous solution by molecular dynamics simulations is presented to suggest structural and energetic factors controlling the formation of nanostructures.

Autore Pugliese

• Giannini Cinzia , Sibillano Teresa

Tutti gli autori

• C. Diaferia; T. Sibillano; N. Balasco; C. Giannini; V. Roviello; L. Vitagliano; G. Morelli; A. Accardo

Titolo volume/Rivista

Chemistry

Anno di pubblicazione

2016

ISSN

0947-6539

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile