Abstract

Halloysite is a nanostructured clay mineralwith hollow tubular structure, which has recently found animportant role as delivery sistem for drugs or other activemolecules. One of these is curcumin, main constituent inthe rhizome of the plant Curcuma Longa, with a series ofuseful pharmacological activities, hindered by its poorsolubility in water and bioavalaibility. In this study,Halloysite Clay Nanotubes (HNTs) were characterized interms of both structure and biocompatibily and they wereused for curcumin delivery to cancer cells. The performedMTT assay showed that HNTs have a high biocompatibility,also when coated with polymers, while curcumin is highlytoxic for cancer cells. The release kinetics of curcuminfrom HNTs was investigated by the dialysis bag method,showing a slow and constant release of the drug, which canbe further controlled by adding layers of polymers to theexternal surface of the tubes. The Trypan Blue assayshowed a cytotoxic effect of loaded HNTs, proportional tothe concentration of tubes and the incubation time.

Autore Pugliese

• Casciaro Sergio

Tutti gli autori

• C. Dionisi; N.A.N. Hanafy; C. Nobile; S.Leporatti; N.A.N. Hanafy; M.L. De Giorgi; R. Rinaldi; S. Casciaro; Y.M. Lvov.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2015

ISSN

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ISBN

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Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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