Abstract

In this preliminary work the toxic activity of PolycyclicAromatic Hydrocarbons (PAHs) mix standard solutionswas studied using "Caenorhabditis elegans" (C. eleguns)as system for biological studies.The nematode cultures were exposed for 3 days to0.01, 0.1 and 1 ppb (nglml) of PAH Mix and even if nomorphological alterations were observed on the C. eleganspopulations, the lethality was about 50% when the PAHsconcentrations were equal to 0.1 and 1 ppb. Moreover, thelethality test was performed using an organic extract froma PM10 sample.When the gene expression pattern was analyzed a downregulation of the expression on all the genes consideredwas observed, indicating that the genotoxic effect was scatteredon the entire transcription mechanism.These results indicate that "C, elegans" is an effectivemodel for the study of PAHs toxicity; future studieswill be oriented to the toxicity evaluation of extracts fromPM2.5 and PM10 samples collected in Apulia cities.

Autore Pugliese

• De Luca Francesca

Tutti gli autori

• Daresta B.E.; Liuzzi V.C.; De Gennaro G.; De Giorgi C.; De Luca F.; Caselli M.

Titolo volume/Rivista

Fresenius environmental bulletin

Anno di pubblicazione

2010

ISSN

1018-4619

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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